GenTegra -Nucleic Acid Stabilization Products

GenTegra-RNA is quite simply the best protection available for your RNA. It is a water soluble Active Chemical Protection that when added to purified RNA allows it to be air-dried to form a protective matrix that preserves RNA in the dry state. The protection is near perfect at the extremes of temperature (-80°C to +56°C) for >4yrs. The protection is unmatched when it comes to protecting against the high temperatures encountered when shipping RNA samples. Independent studies show GenTegra-RNA protects better than shipping on dry ice. GenTegra-RNA is the only dry storage product that provides immediate protection against RNase activity before drying and allows the use of all standard buffer systems. Studies prove conclusively that GenTegra-RNA begins protecting your RNA the instant it is added to the RNA solution and protects RNA long-term better than storage at -20°C or -80°C and you save valuable freezer space. GenTegra-RNA is protected by an awarded US Patent.

All GenTegra-RNA products have a shelf life of 3-years at ambient temperatures

GenTegra-DNA is a water soluble chemical matrix that when added to purified DNA allows it to be air-dried to form a solid matrix which coats, preserves and protects DNA in the dry state at ambient temperatures. The protection is near perfect at the extremes of temperature (-80°C to +56°C) for many years. GenTegra-DNA is especially valuable and effective at protecting against the high temperatures likely to be encountered when shipping samples. Studies prove conclusively that GenTegra-DNA protects DNA better than storage at -20°C or -80°C and you save valuable freezer space. GenTegra-DNA has been protecting DNA samples since 2009 and is protected by an awarded US Patent. All GenTegra-DNA products have an expected shelf life of greater than 3-years at ambient temperatures. Accelerated temperature time studies show protection equivalent to >20 years. GenTegra-DNA has been protecting DNA since 2008 and is protected by an awarded US Patent. No need for a desiccant, ice or dry ice when shipping. And because of the stability at ambient temperatures it simply does not matter if the sample is delayed in shipment, it will still arrive perfectly intact and ready to use.

Once the purified DNA has been combined with the GenTegra-DNA matrix and dried it is stable and protected. And once dried it stays dry because it is not hydroscopic and will not take up water. Long term archiving of the DNA sample does not require either humidity control or desiccant to keep the DNA safe.

All GenTegra-DNA products have a shelf life of 3-years at ambient temperatures.

Collection cards are ideal for field sample collection in areas where a cold chain is unavailable or difficult to maintain. GenTegra offers cards for every need, DNA collection, RNA collection or sample collection for analysis of small molecule metabolites.

Ahlstrom-Munksjö GenSaver Card is the first new technology for collection and long-term storage of DNA in DBS in more than 20 years. GenSaver cards use the highly regarded and proven GenTegra®-DNA Active Chemical Protection™ on superior Ahlstrom paper. When collecting DBS for ambient temperature transportation or long-term DNA storage, this is the card of choice. It provides high levels of protection for the DNA during shipment and storage even at elevated temperatures. DBS on GenSaver cards can be used directly for PCR with no cleanup step required. A small punch can be added directly to the PCR mix without worrying about inhibition of the PCR reaction.

All Ahlstrom-Munksjö specimen collection cards are manufactured to ISO 18385 compliance, ensuring no human DNA contamination, so they are suitable for all forensic specimen collection needs as well as research specimen collection. Collection cards are available in all the common formats to meet your needs. The GenSaver cards are available I 1-spot, 2-spot & 4-spot formats and in color versions for use with clear samples. GenSaver cards also come in a 2.0 version designed for use in forensic applications where the samples may be dirty and need extra protection against microbial contamination.

The GenSolve DNA COMPLETE kit combines the acknowledged superior quality and quantity of DNA extracted by GenSolve with an equally superior column based purification to yield the best and most DNA possible form Dried Blood Spots on paper. The combination is specifically designed to provide the very best results when working with DBS as the sample origin. Highest quality dsDNA can be efficiently recovered at higher yield from treated paper, i.e. GenSaver or FTA, and plain paper, i.e. GenCollect and Guthrie cards than using other techniques. The GenSolve reagents coupled with recovery process enhances digestion of dried biological material and liberates more bound DNA from the paper. The resulting lysate, which is a mixture of DNA, cellular debris and preservation chemicals, if applicable, is then applied directly onto a purification membrane. Subsequent washing steps separate the DNA from cellular material and a final elution step results in purified DNA ready for any genetic analysis techniques or for long term storage using GenTegra-DNA.

Once the purified DNA has been combined with the GenTegra-DNA matrix and dried it is stable and protected. And once dried it stays dry because it is not hydroscopic and will not take up water. Long term archiving of the DNA sample does not require either humidity control or desiccant to keep the DNA safe.

Additionally, you have the convenience of getting everything you need from one vendor.

GenPlates®: are an automation friendly, high density format for biobanking of raw blood, buffy coat, saliva and other fluid biospecimens at room temperature for later extraction of high quality dsDNA. The GenPlate is a high density 384-microplate format with a 6-mm disc of FTA paper in each well. For decades now, FTA paper has been the de-facto standard for protecting DNA that is stored on paper as dried blood spots. GenPlates have been storing and protecting DNA in dried blood spots since 2006, and are protected by US and Int. Patents. GenPlates are available in several formats to best fits the storage needs of your samples.

The FastDryer is a simple, economical and convenient way to dry biosamples following application to GenTegra-DNA or GenTegra-RNA. Each FastDryer will accept one 96-well microplates, one rack of 0.3 ml cluster tubes, one GenPlate or up to 48, 0.5 ml, screw-cap tubes. Most samples of ≤ 50 µl will be dried overnight and be ready for storage in the morning. The FastDryer has been tested and shows no carryover between samples.