Promise Proteomics is a pioneer and expert in mass spectrometry-based quantification methods development and in bioproduction of Stable Isotope Labeled (SIL) monoclonal antibodies (mAbs).
The DIGESTIF standard consists of a soluble recombinant protein scaffold to which a set of 11 artificial peptides (iRT peptides) with good ionization properties has been incorporated. In the protein scaffold, the amino acids flanking iRT peptide cleavage sites were selected to either favor or hinder protease cleavage. After sample processing, the retention time and relative intensity pattern of the released iRT peptides can be used to assess the quality of sample workup, the extent of digestion and the performance of the LC-MS system. So Digestif can be used to standardize a broad spectrum of applications including LC-MS based proteomics, development of peptide mapping protocols and protein biomarker studies.
The DIGESTIF standard consists of a soluble recombinant protein scaffold to which a set of 11 artificial peptides (iRT peptides) with good ionization properties has been incorporated. In the protein scaffold, the amino acids flanking iRT peptide cleavage sites were selected to either favor or hinder protease cleavage. After sample processing, the retention time and relative intensity pattern of the released iRT peptides can be used to assess the quality of sample workup, the extent of digestion and the performance of the LC-MS system.
mAbXmise is an innovation born from the combination of Promise Proteomics’ recognized expertise in mass spectrometry and its unique know-how in the production of internal standards for proteins assays. Today this innovative range is available in clinical practice to assist healthcare professionals in their decision making.